The network has decided not to renew 's Forever for a second season, while Cristela, Resurrection and The Taste have also been axed.
Writing on Twitter, Gruffudd's wife Alice Evans admitted that he is "a little shaken" by the news, adding: "It's brutal, but that's show business."
The actor played Henry Morgan, an immortal New York City medical examiner in the series. Alana de la Garza, Joel David Moore, Donnie Keshawarz, Lorraine Toussaint and Judd Hirsch were also among the cast.
ABC's newest comedy Cristela is also coming to an end after just one season, and Resurrection will not be back for a third season. Culinary competition The Taste is being cancelled after two seasons.
© ABC / Bob D'Amico
Meanwhile, the network has renewed all other series on its current slate, including Castle, Grey's Anatomy, How To Get Away With Murder, Marvel's Agents of SHIELD, Nashville, Once Upon a Time, Scandal, American Crime, Secrets and Lies and Marvel's Agent Carter.
Comedies Black-ish, Fresh Off the Boat, The Goldberg, The Middle, Modern Family and Galavant will also return, along with unscripted series The Bachelor, Dancing With the Stars, America's Funniest Home Videos, Shark Tank, Beyond the Tank and 20/20.
The only show ABC is yet to decide on is Tim Allen sitcom Last Man Standing.
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